Uptake of pertussis immunization in pregnancy and determinants of vaccination in Toronto, Canada

James Wright; Michelle Science; Selma Osman; Callum Arnold; Maya Sumaida; Natasha Crowcroft; Shelley L Deeks; Kevin Brown; Scott Halperin; Todd Hatchette; Elizabeth McLachlan; Aaron Campigotto; Susan Richardson; Shelly Bolotin

doi:10.1016/j.vaccine.2023.10.020

Uptake of pertussis immunization in pregnancy and determinants of vaccination in Toronto, Canada

Vaccine. 2023 Nov 13;41(47):6895-6898. doi: 10.1016/j.vaccine.2023.10.020. Epub 2023 Oct 14.

Authors

Affiliations

¹ Public Health Ontario, Toronto, Ontario, Canada.
² Public Health Ontario, Toronto, Ontario, Canada; Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, University of Toronto, Toronto Canada; Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
³ Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
⁴ Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biology, Pennsylvania State University, University Park, PA 16802, USA; Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA.
⁵ Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
⁶ Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
⁷ Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Community Health and Epidemiology, Dalhousie University.
⁸ Canadian Center for Vaccinology (CCfV), IWK Health Centre, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia (NS), Canada.
⁹ National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
¹⁰ Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto Canada.
¹¹ Public Health Ontario, Toronto, Ontario, Canada; Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto Canada. Electronic address: shelly.bolotin@utoronto.ca.

PMID: 37845156
DOI: 10.1016/j.vaccine.2023.10.020

Abstract

Introduction: Pertussis causes significant morbidity and mortality in infants aged <6 months. Maternal pertussis vaccination during pregnancy has been recommended in Canada since 2018 to reduce these negative outcomes. In the absence of routine immunization coverage data, our objective was to evaluate uptake in Toronto, Canada.

Methods: We recruited mother-infant pairs at The Hospital for Sick Children, Toronto, between 2018 and 2020. We performed logistic regression to examine associations between demographics and self-reported pertussis vaccination.

Results: 76/243 mothers (31.3 %) reported receiving pertussis vaccination during their most recent pregnancy. Odds of receiving vaccination more than doubled with each 1-year increase in year of pregnancy (aOR: 2.2; 95 % CI: 1.3, 3.6; p < 0.01) and among those born in Canada as compared to those not (aOR: 2.0; 95 % CI: 1.1, 3.6; p = 0.02) CONCLUSION: Uptake of pertussis vaccination during pregnancy in Ontario has increased in recent years, however coverage remains lower than desirable.

Keywords: Immunization in pregnancy; Pertussis; Vaccine preventable diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Female
Humans
Immunization
Infant
Mothers
Ontario
Pregnancy
Vaccination
Vaccination Coverage
Whooping Cough* / prevention & control

Grants and funding

CIHR/Canada