177 Lu Radiolabelled AIE Dots for Multimodal Imaging Guided Photothermal/Radiopharmaceutical Tumor Therapy

Haoying Huang; Kaiwu Yu; Elkawad Husamelden; Hong Zhang; Zhengwei Mao; Shunjie Liu; Qinghua Zhang; Mei Tian; Haoke Zhang; Qinggang He

doi:10.1002/asia.202300847

¹⁷⁷ Lu Radiolabelled AIE Dots for Multimodal Imaging Guided Photothermal/Radiopharmaceutical Tumor Therapy

Chem Asian J. 2023 Dec 1;18(23):e202300847. doi: 10.1002/asia.202300847. Epub 2023 Nov 2.

Authors

Haoying Huang¹, Kaiwu Yu², Elkawad Husamelden¹, Hong Zhang^{1

3}, Zhengwei Mao³, Shunjie Liu⁴, Qinghua Zhang², Mei Tian¹, Haoke Zhang¹, Qinggang He²

Affiliations

¹ Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
² College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P. R. China.
³ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P.R. China.
⁴ Key Laboratory of Polymer Ecomaterial, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.

PMID: 37842968
DOI: 10.1002/asia.202300847

Abstract

Aggregation-induced emission luminogens (AIEgens) in the second near-infrared region (NIR-II,1000-1700 nm) have shown tremendous potential as theragnostic probe for tumor multimodal diagnostic imaging and combined treatment owing to their programmable optical, structural and functional properties. Herein, we presented a radionuclide ¹⁷⁷ Lu-labeled AIEgen, ¹⁷⁷ Lu-2TT-oC6B dots, for NIR-II fluorescence and SPECT/CT imaging-guided tumor photothermal and radiopharmaceutical therapy. Intriguingly, ¹⁷⁷ Lu-2TT-oC6B self-assembled into 10 nm dots, exhibited high NIR-II fluorescence quantum yield (QY, 1.34 %) and unprecedented photothermal conversion efficiency (PCE, 70.3 %) in vitro, furtherly performed extremely long blood circulation (T_1/2 =52.4 h), persistent tumor accumulation and retention in tumor (NIR-II SNR=5.56; SPECT SNR=36.59) via intravenous administration in vivo. Furthermore, upon NIR light activation and ¹⁷⁷ Lu irradiation, ¹⁷⁷ Lu-2TT-oC6B demonstrated great application potential in synergistic photothermal/radiopharmaceutical tumor therapy.

Keywords: aggregation-induced emission (AIE); multi-modality imaging; single-photon emission computed tomography (SPECT); the second near-infrared fluorescence (NIR-II FL); theragnostic.

MeSH terms

Humans
Multimodal Imaging
Nanoparticles* / chemistry
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Optical Imaging / methods
Photothermal Therapy
Radiopharmaceuticals / pharmacology

Substances

Radiopharmaceuticals

Abstract

MeSH terms

Substances

Grants and funding