Convergent Klebsiella pneumoniae strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence

Katharina Schaufler; Thaddäus Echelmeyer; Michael Schwabe; Sebastian Guenther; Jürgen A Bohnert; Karsten Becker; Helmut Fickenscher; Aike Bueter; Gregor Maschkowitz; Andi Krumbholz; Dennis Nurjadi; Stefan E Heiden; Elias Eger

doi:10.1080/22221751.2023.2271096

Convergent Klebsiella pneumoniae strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence

Emerg Microbes Infect. 2023 Dec;12(2):2271096. doi: 10.1080/22221751.2023.2271096. Epub 2023 Oct 31.

Authors

Katharina Schaufler^{1

2

3

4}, Thaddäus Echelmeyer², Michael Schwabe², Sebastian Guenther⁵, Jürgen A Bohnert⁶, Karsten Becker⁶, Helmut Fickenscher¹, Aike Bueter¹, Gregor Maschkowitz¹, Andi Krumbholz^{1

7}, Dennis Nurjadi⁸, Stefan E Heiden³, Elias Eger^{1

3}

Affiliations

¹ Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.
² Institute of Pharmacy, Pharmaceutical Microbiology, University of Greifswald, Greifswald, Germany.
³ Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research HZI, Greifswald, Germany.
⁴ University Medicine Greifswald, Greifswald, Germany.
⁵ Institute of Pharmacy, Pharmaceutical Biology, University of Greifswald, Greifswald, Germany.
⁶ Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
⁷ Labor Dr. Krause und Kollegen MVZ GmbH, Kiel, Germany.
⁸ Department of Infectious Diseases and Microbiology, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.

No abstract available

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Carbapenems / pharmacology
Cefiderocol
Cephalosporins*
Disease Outbreaks
Klebsiella pneumoniae* / genetics
Multilocus Sequence Typing
beta-Lactamases / genetics

Substances

Cephalosporins
Anti-Bacterial Agents
Carbapenems
beta-Lactamases

Grants and funding

This work and the position of MS was supported by a grant from the Federal Ministry of Education and Research (BMBF) to KS entitled “Disarming pathogens as a different strategy to fight antimicrobial-resistant Gram-negatives” Bundesministerium für Bildung und Forschung: [grant no 01KI2015].