Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations - a systematic review

Magdalena Stasiak; Bartłomiej Stasiak; Katarzyna Zawadzka-Starczewska; Andrzej Lewiński

doi:10.3389/fimmu.2023.1256922

Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations - a systematic review

Front Immunol. 2023 Sep 28:14:1256922. doi: 10.3389/fimmu.2023.1256922. eCollection 2023.

Authors

Magdalena Stasiak¹, Bartłomiej Stasiak², Katarzyna Zawadzka-Starczewska¹, Andrzej Lewiński^{1

3}

Affiliations

¹ Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland.
² Institute of Information Technology, Lodz University of Technology, Lodz, Poland.
³ Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.

Abstract

Introduction: Graves' disease (GD) and Graves' orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic typing, which led to inconsistent results even among the same population. The present review is intended to summarize the state-of-art knowledge on the HLA significance in GD and GO in Asians and Caucasians, as well as to find the most significant alleles for each of the populations.

Methods: PubMed was searched for relevant articles using the following search terms: HLA plus thyroid-associated ophthalmopathy or Graves' disease or Graves' orbitopathy or thyroid eye disease or thyroid-associated orbitopathy.

Results: In Asian population GD was found to be associated mostly with B*46:01, DPB1*05:01, DRB1*08:02/03, DRB1*16:02, DRB1*14:03, DRB1*04:05, DQB1*05:02 and DQB1*03:03, while DRB1*07:01, DRB1*01:01, DRB1*13:02, DRB1*12:02 are potentially protective. HLA-B*38:02, DRB1*16:02, DQA1*01:02, DQB1*05:02 can be considered associated with increased risk of GO in Asians, while HLA-B*54:01 may play protective role. In Caucasians, C*07:01, DQA1*05:01, DRB1*03, DQB1*02:01 are associated with GD risk while DRB1*07:01, DQA1*02:01 may be protective. Significance of HLA in the course of GD and novel aspects of HLA amino acid variants and potential HLA-based treatment modalities were also discussed.

Keywords: Asian population; Caucasian population; Graves’ disease; Graves’ orbitopathy; HLA; genotyping; human leukocyte antigen.

Publication types

Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Graves Disease* / genetics
Graves Ophthalmopathy* / genetics
HLA-B Antigens / genetics
HLA-DQ Antigens / genetics
HLA-DRB1 Chains / genetics
Haplotypes
Humans

Substances

HLA-DQ Antigens
HLA-DRB1 Chains
HLA-B Antigens

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This review was financially supported by the Polish Mother’s Memorial Hospital-Research Institute, Lodz, Poland.