Metal nanoparticles and carbohydrate polymers team up to improve biomedical outcomes

Seid Reza Falsafi; Fuat Topuz; Dagmara Bajer; Zahra Mohebi; Maryam Shafieiuon; Hajar Heydari; Shruti Rawal; Anbazhagan Sathiyaseelan; Myeong-Hyeon Wang; Rubiya Khursheed; M H Enayati; Hadis Rostamabadi

doi:10.1016/j.biopha.2023.115695

Metal nanoparticles and carbohydrate polymers team up to improve biomedical outcomes

Biomed Pharmacother. 2023 Dec:168:115695. doi: 10.1016/j.biopha.2023.115695. Epub 2023 Oct 14.

Authors

Affiliations

¹ Safiabad Agricultural Research and Education and Natural Resources Center, Agricultural Research, Education and Extension Organization (AREEO), Dezful P.O. Box 333, Iran.
² Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Sariyer 34469, Istanbul, Turkey.
³ Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
⁴ Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
⁵ Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
⁶ Department of Pharmaceutical Technology, L.J. Institute of Pharmacy, L J University, Ahmedabad 382210, India; Department of Pharmaceutics, Institute of Pharmacy, Nirma University, S.G. Highway, Chharodi, Ahmedabad, Gujarat 382481, India.
⁷ Department of Bio-Health Convergence, Kangwon National University, Chuncheon 200-701, South Korea.
⁸ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.
⁹ Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. Electronic address: rostamabadi@nutr.mui.ac.ir.

PMID: 37839113
DOI: 10.1016/j.biopha.2023.115695

Abstract

The convergence of carbohydrate polymers and metal nanoparticles (MNPs) holds great promise for biomedical applications. Researchers aim to exploit the capability of carbohydrate matrices to modulate the physicochemical properties of MNPs, promote their therapeutic efficiency, improve targeted drug delivery, and enhance their biocompatibility. Therefore, understanding various attributes of both carbohydrates and MNPs is the key to harnessing them for biomedical applications. The many distinct types of carbohydrate-MNP systems confer unique capabilities for drug delivery, wound healing, tissue engineering, cancer treatment, and even food packaging. Here, we introduce distinct physicochemical/biological properties of carbohydrates and MNPs, and discuss their potentials and shortcomings (alone and in combination) for biomedical applications. We then offer an overview on carbohydrate-MNP systems and how they can be utilized to improve biomedical outcomes. Last but not least, future perspectives toward the application of such systems are highlighted.

Keywords: Biomedical applications; Carbohydrate polymers; Metal nanoparticles.

Publication types

Review

MeSH terms

Carbohydrates
Drug Delivery Systems
Magnetite Nanoparticles* / chemistry
Metal Nanoparticles*
Nanoparticles*
Polymers
Tissue Engineering

Substances

Magnetite Nanoparticles
Polymers
Carbohydrates