Synergistic effect of lactoferrin and osteopontin on intestinal barrier injury

Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127416. doi: 10.1016/j.ijbiomac.2023.127416. Epub 2023 Oct 13.

Abstract

Several studies indicate that the disruption of the intestinal epithelial barrier can lead to inflammatory bowel disease (IBD). Recent evidence has increasingly demonstrated that lactoferrin (LF) and osteopontin (OPN) can alleviate intestinal barrier injury. However, the potential synergistic effects of these two proteins and the mechanisms underlying their effects remain unclear. To address this question, we developed a lipopolysaccharide-induced intestinal barrier injury model in C57BL/6 N mice. Our findings demonstrated that the combination of LF and OPN at a 1:5 ratio exerts the strongest protective effect on the intestinal barrier, and it is more effective than LF or OPN alone. This protection is evidenced by the decrease in serum diamine oxidase (DAO) activity (1.66-fold decrease) and D-lactic content (1.51-fold decrease) and the reduced rate of FITC-labeled glucan transport across the jejunum (3.18-fold decrease). Moreover, the protein combination significantly promoted villi length (1.66-fold increase) and crypt depth (1.57-fold increase), improved tight junction protein structure and expression, and boosted the number of absorptive cells (4.34-fold increase) in the intestinal epithelium. Furthermore, the combination promoted crypt cell proliferation and differentiation via Notch signaling. In summary, our findings provide scientific evidence supporting the use of dietary intervention strategies for preventing IBD.

Keywords: Intestinal barrier injury; Lactoferrin; Osteopontin.

MeSH terms

  • Animals
  • Inflammatory Bowel Diseases* / metabolism
  • Intestinal Mucosa / metabolism
  • Intestines
  • Lactoferrin / metabolism
  • Lactoferrin / pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Osteopontin* / metabolism

Substances

  • Osteopontin
  • Lactoferrin