A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Molecules. 2023 Sep 27;28(19):6816. doi: 10.3390/molecules28196816.

Abstract

Traditional Chinese medicine (TCM) is a class of natural drugs with multiple components and significant therapeutic effects through multiple targets. It also originates from a wide range of sources containing plants, animals and minerals, and among them, plant-based Chinese medicine also includes fungi. Fungal traditional Chinese medicine is a medicinal resource with a long history and widespread application in China. Accumulating evidence confirms that polysaccharide is the main pharmacodynamic material on which fungal TCM is based. The purpose of the current systematic review is to summarize the extraction, isolation, structural identification, biological functions, quality control and medicinal and edible applications of polysaccharides from fungal TCM in the past three years. This paper will supplement and deepen the understanding and application of polysaccharides from fungal TCM, and propose some valuable insights for further research and development of drugs and functional foods.

Keywords: application; biological functions; fungal traditional Chinese medicine; polysaccharide; quality control; structural identification.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Animals
  • China
  • Drugs, Chinese Herbal* / pharmacology
  • Drugs, Chinese Herbal* / therapeutic use
  • Medicine, Chinese Traditional*
  • Polysaccharides / chemistry
  • Quality Control

Substances

  • Drugs, Chinese Herbal
  • Polysaccharides

Grants and funding

This work was financially supported by the Chief Scientist of Qi-Huang Project of National Traditional Chinese Medicine Inheritance and Innovation “One Hundred Million” Talent Project (Grant Number: (2021) No. 7), Qi-Huang Scholar of National Traditional Chinese Medicine Leading Talents Support Program (Grant Number: (2018) No. 284), National Famous Old Traditional Chinese Medicine Experts Inheritance Studio Construction Program of National Administration of TCM (Grant Number: (2022) No. 75), The Seventh Batch of National Famous Old Traditional Chinese Medicine Experts Experience Heritage Construction Program of National Administration of TCM (Grant Number: (2022) No. 76) and Heilongjiang Touyan Innovation Team Program (Grant Number: (2019) No. 5).