The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study

Po-Lin Chiang; Wen-Rui Hao; Hong-Jye Hong; Chun-Chao Chen; Chun-Chih Chiu; Yu-Ann Fang; Tsung-Lin Yang; Yu-Hsin Lai; Ming-Yao Chen; Min-Huei Hsu; Kuan-Rau Chiou; Kuan-Jie Lin; Tsung-Yeh Yang; Hsin Hsiu; Ju-Chi Liu

doi:10.3390/cancers15194728

The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study

Cancers (Basel). 2023 Sep 26;15(19):4728. doi: 10.3390/cancers15194728.

Authors

Po-Lin Chiang^{1

2}, Wen-Rui Hao^{1

3

4}, Hong-Jye Hong⁵, Chun-Chao Chen^{1

3

4

6}, Chun-Chih Chiu^{1

3}, Yu-Ann Fang^{1

3}, Tsung-Lin Yang^{3

4

7}, Yu-Hsin Lai^{8

9

10}, Ming-Yao Chen^{8

9

10}, Min-Huei Hsu^{11

12}, Kuan-Rau Chiou^{1

3

4}, Kuan-Jie Lin^{3

13}, Tsung-Yeh Yang^{1

3}, Hsin Hsiu¹⁴, Ju-Chi Liu^{1

3

4}

Affiliations

¹ Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
² Department of General Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
³ Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan.
⁴ Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁵ School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung City 404333, Taiwan.
⁶ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁷ Division of Cardiology, Department of Internal Medicine and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan.
⁸ Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁹ TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 11031, Taiwan.
¹⁰ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City 23561, Taiwan.
¹¹ Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei 11031, Taiwan.
¹² Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
¹³ Division of Cardiovascular Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
¹⁴ Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan.

Abstract

The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23-1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82-1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31-1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17-1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77-1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.

Keywords: colorectal cancer; insomnia; malignancy; sleep apnea; sleep disorder.

Grants and funding

This work was financially supported by the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan, the 112FRP-01-3 from the Taipei Medical University-Shuang Ho Hospital.