Clinical Features of Severe Ovarian Hyperstimulation Syndrome with Hydrothorax

Xiaowei Ma; Jingwen Yin; Rui Yang; Shuo Yang; Jia Li; Yang Wang; Rong Li

doi:10.3390/jcm12196210

Clinical Features of Severe Ovarian Hyperstimulation Syndrome with Hydrothorax

J Clin Med. 2023 Sep 26;12(19):6210. doi: 10.3390/jcm12196210.

Authors

Xiaowei Ma^{1

2

3

4}, Jingwen Yin^{1

2

3

4}, Rui Yang^{1

2

3

4}, Shuo Yang^{1

2

3

4}, Jia Li^{1

2

3

4}, Yang Wang^{1

2

3

4}, Rong Li^{1

2

3

4}

Affiliations

¹ Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
² National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
³ Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, China.
⁴ Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.

Abstract

Problem: Does the presence of hydrothorax suggest that severe ovarian hyperstimulation syndrome (OHSS) is associated with more severe conditions and worse pregnancy outcomes?

Method of study: The clinical data for 868 hospital patients with severe OHSS following IVF-ET at Peking University Third Hospital between 1 January 2016 and 21 July 2021 were retrospectively analysed. The patients were divided into two groups, the ascites alone group (n = 417) and the ascites combined with hydrothorax group (n = 451), to investigate the clinical features and pregnancy outcomes of patients with severe ovarian hyperstimulation syndrome (OHSS) combined with hydrothorax plus ascites.

Results: The clinical data for 868 hospital patients with severe OHSS following IVF-ET were included. A total of 51.96% of patients with severe OHSS had hydrothorax plus ascites, mainly bilateral and moderate hydrothorax. Most cases with hydrothorax could be monitored and observed, and only 2.66% of the cases required thoracentesis and pleural drainage. Clinically, the time to visit due to worsening symptoms was longer; the hospital stay was shorter; and the OHSS-related laboratory tests, such as white blood cells (WBC), haematocrit (HCT), and ovarian diameter, were less severe in the ascites combined with hydrothorax group than in the ascites alone group. For live-birth outcomes of IVF-ET, the presence and the volume of hydrothorax were not independent risk factors, while the late onset of OHSS (odds ratio [OR]: 0.857 95% confidence interval [CI]: 0.795, 0.925) and a history of foetal reduction (OR: 13.796 95% CI: 1.808, 105.288) were independent protective factors for live birth.

Conclusions: Patients with severe OHSS combined with hydrothorax plus ascites have less severe clinical manifestations and laboratory tests than those with ascites alone. The presence and the volume of hydrothorax are unrelated to live-birth outcomes following in vitro fertilization and embryo transfer (IVF-ET).

Keywords: IVF; OHSS; clinical features; hydrothorax; live birth.

Abstract

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