Nanoparticle encapsulation using self-assembly abietic acid to improve oral bioavailability of curcumin

Ying Han; Hua Zhang; Haitian Zhao; Shiyao Fu; Ruiling Li; Zhili Wang; Yangxin Wang; Weihong Lu; Xin Yang

doi:10.1016/j.foodchem.2023.137676

Nanoparticle encapsulation using self-assembly abietic acid to improve oral bioavailability of curcumin

Food Chem. 2024 Mar 15:436:137676. doi: 10.1016/j.foodchem.2023.137676. Epub 2023 Oct 4.

Authors

Ying Han¹, Hua Zhang², Haitian Zhao³, Shiyao Fu¹, Ruiling Li⁴, Zhili Wang⁴, Yangxin Wang⁴, Weihong Lu², Xin Yang⁵

Affiliations

¹ School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
² School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
³ School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China; Chongqing Research Institute, Harbin Institute of Technology, Chongqing 401135, China.
⁴ School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.
⁵ School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China; Chongqing Research Institute, Harbin Institute of Technology, Chongqing 401135, China. Electronic address: yangxin@hit.edu.cn.

PMID: 37832417
DOI: 10.1016/j.foodchem.2023.137676

Abstract

This research constructed composite nanoparticles (NPs) using abietic acid (AA) as a carrier for significantly enhancing the bioavailability of curcumin (CCM). CCM-loaded AA NPs were synthesized using a low-energy microemulsification method, and the obtained nanoparticles had a spherical morphology with an average diameter of 458.66 nm, a narrow size distribution and a negative surface charge of -19.13 mV. The encapsulation efficiency of CCM was 17.98 %, while its solubility was 20-fold that of free curcumin. FITR, UV, and MD revealed hydrogen bonds and hydrophobic forces between AA and CCM. Thein-vitrorelease profile showed sustainable release of CCM in simulated gastric and intestinal fluids up to 2 h at 37 °C. In cellular studies, CCM-loaded AA NPs with the same CCM concentration exhibited greater bioaccessibility and bioavailability than free CCM. These data suggested a possible utilization of AA NPs in improving water solubility, bioavailability and activity of lipophilic bioactive food factors.

Keywords: Abietic acid; Assembly; Bio ability; Curcumin; Natural small molecule.

MeSH terms

Biological Availability
Curcumin* / chemistry
Drug Carriers / chemistry
Nanoparticles* / chemistry
Particle Size

Substances

Curcumin
Drug Carriers
abietic acid