The Nuclear Cap-Binding Complex, a multitasking binding partner of RNA polymerase II transcripts

J Biochem. 2023 Dec 20;175(1):9-15. doi: 10.1093/jb/mvad081.

Abstract

In eukaryotic cells, RNAs transcribed by RNA polymerase-II receive the modification at the 5' end. This structure is called the cap structure. The cap structure has a fundamental role for translation initiation by recruiting eukaryotic translation initiation factor 4F (eIF4F). The other important mediator of the cap structure is a nuclear cap-binding protein complex (CBC). CBC consists of two proteins, which are renamed as NCBP1 and NCBP2 (previously called as CBP80/NCBP and CBP20/NIP1, respectively). This review article discusses the multiple roles CBC mediates and co-ordinates in several gene expression steps in eukaryotes.

Keywords: 7-methyl guanosine (m7G) cap; RNA polymerase II; cap-binding protein complex (CBC); eIF4E; gene expression.

Publication types

  • Review

MeSH terms

  • Eukaryotic Cells / metabolism
  • Nuclear Cap-Binding Protein Complex / chemistry
  • Nuclear Cap-Binding Protein Complex / genetics
  • Nuclear Cap-Binding Protein Complex / metabolism
  • RNA Caps* / chemistry
  • RNA Caps* / genetics
  • RNA Caps* / metabolism
  • RNA Polymerase II* / metabolism

Substances

  • RNA Caps
  • RNA Polymerase II
  • Nuclear Cap-Binding Protein Complex