Gut IgA: Never fear, the super inducers are here

Pablo Canales-Herrerias; Andrea Cerutti

doi:10.1016/j.chom.2023.09.004

Gut IgA: Never fear, the super inducers are here

Cell Host Microbe. 2023 Oct 11;31(10):1595-1597. doi: 10.1016/j.chom.2023.09.004.

Authors

Pablo Canales-Herrerias¹, Andrea Cerutti²

Affiliations

¹ Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Translational Clinical Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address: acerutti@imim.es.

PMID: 37827118
DOI: 10.1016/j.chom.2023.09.004

Abstract

In this issue of Cell Host & Microbe, Zhang et al. show that long-term oral administration of a pectin-derived prebiotic broadly enhanced IgA responses to commensals in the small intestine. This effect required T cells and involved Lachnospiraceae A2, suggesting that a few symbionts promote IgA responses to many commensals.

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MeSH terms

Fear
Immunoglobulin A*
Intestine, Small*
Prebiotics
T-Lymphocytes

Substances

Immunoglobulin A
Prebiotics