The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

Front Immunol. 2023 Sep 26:14:1271051. doi: 10.3389/fimmu.2023.1271051. eCollection 2023.

Abstract

Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.

Keywords: adipocytokines (adipokines); brown adipose tissue (BAT); cardiovascular disease; perivascular adipose tissue (PVAT); white adipose tissue (WAT).

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / metabolism
  • Adipokines / metabolism
  • Adipose Tissue / metabolism
  • Cardiovascular Diseases* / metabolism
  • Humans
  • Signal Transduction

Substances

  • Adipokines

Grants and funding

This work was partially supported by Shandong Provincial Natural Science Foundation, China (Number ZR2021QB122) and grants from Strengthening Foundation Plan for Young Teachers of School of Pharmacy (Number 2021-0004).