Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC

Jayanthi Pazhani; Vishnu Priya Veeraraghavan; Selvaraj Jayaraman

doi:10.6026/97320630019464

Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC

Bioinformation. 2023 Apr 30;19(4):464-466. doi: 10.6026/97320630019464. eCollection 2023.

Authors

Jayanthi Pazhani¹, Vishnu Priya Veeraraghavan¹, Selvaraj Jayaraman¹

Affiliation

¹ Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.

Abstract

Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3β, β-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These results suggest that targeting the wnt signaling downstream targets with proflavine might leads to the better outcome for therapeutic outcome for the inhibition of invasion and metastasis in oral squamous cell carcinoma.

Keywords: Oral carcinoma; molecular docking; proflavine; wnt signaling.