Tbx1 orchestrates an immune niche that safeguards a broken heart

Sara Perrotta; Daniela Carnevale

doi:10.1016/j.immuni.2023.09.008

Tbx1 orchestrates an immune niche that safeguards a broken heart

Immunity. 2023 Oct 10;56(10):2177-2179. doi: 10.1016/j.immuni.2023.09.008.

Authors

Sara Perrotta¹, Daniela Carnevale²

Affiliations

¹ Department of Angiocardioneurology and Translational Medicine, Unit of Neuro and Cardiovascular Pathophysiology, IRCCS Neuromed, 86077 Pozzilli, Italy.
² Department of Angiocardioneurology and Translational Medicine, Unit of Neuro and Cardiovascular Pathophysiology, IRCCS Neuromed, 86077 Pozzilli, Italy; Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy. Electronic address: daniela.carnevale@uniroma1.it.

PMID: 37820578
DOI: 10.1016/j.immuni.2023.09.008

Abstract

Cardiac lymphatics cooperate with the reparative immune response in myocardial healing after infarction. In this issue of Immunity, Wang and colleagues discover a mechanism underlying this cooperation, dependent on the transcription factor Tbx1 and responsible for the creation of an immunosuppressive niche that mitigates autoimmunity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Heart* / physiology
Myocardium
T-Box Domain Proteins* / genetics
Transcription Factors

Substances

T-Box Domain Proteins
Transcription Factors