Specimen sharing for epidemic preparedness: Building a virtual biorepository system from local governance to global partnerships

PLOS Glob Public Health. 2023 Oct 11;3(10):e0001568. doi: 10.1371/journal.pgph.0001568. eCollection 2023.

Abstract

We present a framework for a federated, virtual biorepository system (VBS) with locally collected and managed specimens, as a 'global public good' model based on principles of equitable access and benefit sharing. The VBS is intended to facilitate timely access to biological specimens and associated data for outbreak-prone infectious diseases to accelerate the development and evaluation of diagnostics, assess vaccine efficacy, and to support surveillance and research needs. The VBS is aimed to be aligned with the WHO BioHub and other specimen sharing efforts as a force multiplier to meet the needs of strengthening global tools for countering epidemics. The purpose of our initial research is to lay the basis of the collaboration, management and principles of equitable sharing focused on low- and middle-income country partners. Here we report on surveys and interviews undertaken with biorepository-interested parties to better understand needs and barriers for specimen access and share examples from the ZIKAlliance partnership on the governance and operations of locally organized biorepositories.

Grants and funding

The work was partially funded by the European Union Horizon 2020 Research and Innovation Programme under Grant Agreement No. 825746, and is supported by the Canadian Institutes of Health Research, Institute of Genetics (CIHR-IG) under Grant Agreement No. 01886-000.