Proliferative verrucous leukoplakia (PVL) is one of the oral potentially malignant disorders (OPMD) with the highest malignant potential. PVL tends to be easily misdiagnosed owing to the resemblance in clinical manifestations between PVL and other diseases such as oral leukoplakia or oral lichen planus. PVL is considered as a special type of oral leukoplakia by some scholars, which is characterized by its tendency of recurrence and metastasis, along with its high risk of malignant transformation. So far, the accurate clinic diagnosis and management of PVL are still intractable due to the lack of definite histopathological definition, unified diagnostic criteria and effective treatment modalities. This review aims to provide the clinical practitioners with a series of advices on the clinical diagnosis and management of PVL by systematically reviewing the diagnostic logistics, therapeutic strategies, malignant transformation detection based on tremendous relevant data and evidence-based medicine.
增殖性疣状白斑（proliferative verrucous leukoplakia，PVL）是口腔潜在恶性疾患（oral potentially malignant disorders，OPMD）中恶变率较高的疾病之一。因PVL与口腔白斑病、口腔扁平苔藓等临床表现相似，易被误诊为其他疾病。有学者认为PVL是口腔白斑病的一种特殊类型，特征是易复发、扩散和具有高恶性转化率。目前，PVL缺乏明确的组织病理学定义、统一的诊断标准和明确有效的治疗方案，临床诊断和治疗存在困难。本文通过系统回顾PVL的诊断标准、治疗方法、恶性转化监测等方面的新进展，以期为临床医师提供PVL临床诊断和治疗方面的实用建议。.