Coagulation factors II, V, VII, IX, X and XI and mortality - a cohort study

Eng Soo Yap; Willem M Lijfering; Frits R Rosendaal; Suzanne C Cannegieter

doi:10.1016/j.rpth.2023.102193

Coagulation factors II, V, VII, IX, X and XI and mortality - a cohort study

Res Pract Thromb Haemost. 2023 Aug 30;7(6):102193. doi: 10.1016/j.rpth.2023.102193. eCollection 2023 Aug.

Authors

Eng Soo Yap^{1

2}, Willem M Lijfering^{1

3}, Frits R Rosendaal^{1

4}, Suzanne C Cannegieter^{1

4

5}

Affiliations

¹ Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Laboratory Medicine, National University Hospital, Singapore.
³ Kennisinstituut van de Federatie Medisch Specialisten, Utrecht, The Netherlands.
⁴ Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
⁵ Thrombosis and Haemostasis Research Center, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Background: Elevated levels of coagulation factors (F) II (FII), FV, FVII, FIX, FX, and FXI have often been related with coronary heart disease, ischemic stroke, and venous thrombosis (VT). However, there are few studies on their associations with all-cause mortality.

Objective: We explored whether elevated levels of FII, FV, FVII, FIX, FX, and FXI are associated with an increased risk of death in patients who had VT and in individuals from the general population.

Methods: We followed 1919 patients with previous VT and 2800 age- and sex-matched community controls in whom coagulation factor levels were measured. A high coagulation factor was defined as the >90th percentile of normal in the controls. Cox regression analyses were adjusted for age and sex and for being a patient with VT or being a control subject.

Results: The median age at time of enrolment was 48 years for both patients and controls, and slightly more women than men were followed. Over a median follow-up of 6.1 years for patients and 5.0 years for controls, there were 79 and 60 deaths in patient and controls respectively. There was no association of FII, FV, FVII, FIX, FX, and FXI with all-cause mortality in patients or in control individuals.

Conclusions: Elevated levels of FII, FV, FVII, FIX, FX, and FXI levels may not be associated with an increased risk of all-cause mortality. Only for cardiac death, an association with high FX and FXI was found, which confirms the findings of previous studies, but numbers were small.

Keywords: epidemiology; factor II; factor IX; factor V; factor VII; factor X; factor XI; mortality.