Diabetic Pneumopathy- A Novel Diabetes-associated Complication: Pathophysiology, the Underlying Mechanism and Combination Medication

Jyotsana Dwivedi; Pranay Wal; Biswajit Dash; Mohammad Ovais; Pranjal Sachan; Vaibhav Verma

doi:10.2174/0118715303265960230926113201

Diabetic Pneumopathy- A Novel Diabetes-associated Complication: Pathophysiology, the Underlying Mechanism and Combination Medication

Endocr Metab Immune Disord Drug Targets. 2023 Oct 10. doi: 10.2174/0118715303265960230926113201. Online ahead of print.

Authors

Jyotsana Dwivedi¹, Pranay Wal¹, Biswajit Dash², Mohammad Ovais³, Pranjal Sachan¹, Vaibhav Verma⁴

Affiliations

¹ PSIT- Pranveer Singh Institute of Technology (Pharmacy), Kanpur, India.
² Department of Pharmaceutical Technology, ADAMAS University, West Bengal, India.
³ Chhatrapati Shahu Ji Maharaj University, Kanpur, India.
⁴ Central University of South Bihar, Gaya, India.

PMID: 37817659
DOI: 10.2174/0118715303265960230926113201

Abstract

Background: The "diabetic lung" has been identified as a possible target organ in diabetes, with abnormalities in ventilation control, bronchomotor tone, lung volume, pulmonary diffusing capacity, and neuroadrenergic bronchial innervation.

Objective: This review summarizes studies related to diabetic pneumopathy, pathophysiology and a number of pulmonary disorders including type 1 and type 2 diabetes.

Methodology: Electronic searches were conducted on databases such as Pub Med, Wiley Online Library (WOL), Scopus, Elsevier, ScienceDirect, and Google Scholar using standard keywords "diabetes," "diabetes Pneumopathy," "Pathophysiology," "Lung diseases," "lung infection" for review articles published between 1978 to 2023 very few previous review articles based their focus on diabetic pneumopathy and its pathophysiology.

Results: Globally, the incidence of diabetes mellitus has been rising. It is a chronic, progressive metabolic disease. The "diabetic lung" may serve as a model of accelerated ageing since diabetics' rate of respiratory function deterioration is two to three-times higher than that of normal, non-smoking people.

Conclusion: Diabetes-induced pulmonary dysfunction has not gained the attention it deserves due to a lack of proven causality and changes in cellular properties. The mechanism underlying a particular lung illness can still only be partially activated by diabetes but there is evidence that hyperglycemia is linked to pulmonary fibrosis in diabetic people.

Keywords: Diabetes; Diabetes Pneumopathy; Lung diseases; Lung infection; Pathophysiology; Pulmonary fibrosis..