The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

Alessio Ciulli; Suzanne O'Connor; Chun-Wa Chung; Ingo V Hartung; Andrea Testa; Danette L Daniels; Laura H Heitman

doi:10.1002/cmdc.202300464

The 17^th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

ChemMedChem. 2023 Oct 17;18(20):e202300464. doi: 10.1002/cmdc.202300464. Epub 2023 Oct 10.

Authors

Alessio Ciulli¹, Suzanne O'Connor¹, Chun-Wa Chung², Ingo V Hartung³, Andrea Testa⁴, Danette L Daniels⁵, Laura H Heitman⁶

Affiliations

¹ Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, DD1 5JJ Scotland, UK.
² GSK R&D, Gunnelswood Road, Stevenage, SG5 4HT, UK.
³ Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
⁴ Amphista Therapeutics Ltd., Cori Building, Granta Park, Great Abington, Cambridge, CB21 6GQ, UK.
⁵ Foghorn Therapeutics, 500 Technology Square, Cambridge, MA 02139, USA.
⁶ Oncode Institute & Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), P. O. Box 9502, 2300RA, Leiden, The Netherlands.

PMID: 37817354
DOI: 10.1002/cmdc.202300464

Abstract

The 17^th EFMC Short Course on Medicinal Chemistry took place April 23-26, 2023 in Oegstgeest, near Leiden in the Netherlands. It covered for the first time the exciting topic of Targeted Protein Degradation (full title: Small Molecule Protein Degraders: A New Opportunity for Drug Design and Development). The course was oversubscribed, with 35 attendees and 6 instructors mainly from Europe but also from the US and South Africa, and representing both industry and academia. This report summarizes the successful event, key lectures given and topics discussed.

Keywords: PROTACs; drug design; medicinal chemistry; molecular glues; protein degraders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Pharmaceutical*
Drug Design*
Europe
Proteolysis
South Africa