Mechanobiology: Border crosstalk protects the nucleus from stress

Katrin Rietscher; Thomas M Magin

doi:10.1016/j.cub.2023.08.008

Mechanobiology: Border crosstalk protects the nucleus from stress

Curr Biol. 2023 Oct 9;33(19):R1002-R1004. doi: 10.1016/j.cub.2023.08.008.

Authors

Katrin Rietscher¹, Thomas M Magin²

Affiliations

¹ Institute of Biology, Division of Cell and Developmental Biology, Leipzig University, Leipzig, Germany.
² Institute of Biology, Division of Cell and Developmental Biology, Leipzig University, Leipzig, Germany. Electronic address: t.magin@uni-leipzig.de.

PMID: 37816316
DOI: 10.1016/j.cub.2023.08.008

Abstract

A new study reports that the extracellular matrix component laminin-111 shields the nucleus from actin-mediated forces by engaging the keratin cytoskeleton. Thus, matrix composition represents a means by which tissues can protect cell nuclei from mechanical damage.

MeSH terms

Actins*
Biophysics
Cell Nucleus
Cell Physiological Phenomena
Cytoskeleton*
Extracellular Matrix
Microtubules
Stress, Mechanical

Substances

Actins