Female and Male Phenotypes of Iron Deficiency in CHF. Additional analysis of the «The Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (J-CHF-RF)» study
Kardiologiia. 2023 Sep 30;63(9):3-13.
doi: 10.18087/cardio.2023.9.n2413.
[Article in
Russian,
English]
Authors
Yu L Begrambekova
1
, Yu V Mareev
2
, V Yu Mareev
1
, Ya A Orlova
1
, Zh D Kobalava
3
, L V Karapetyan
3
, S A Galochkin
3
, E R Kazakhmedov
3
, A A Lapshin
3
, A A Garganeeva
4
, E A Kuzheleva
4
, A A Efremushkina
5
, E V Kiseleva
6
, O L Barbarash
7
, T B Pecherina
7
, A S Galyavich
8
, Z M Galeeva
8
, L V Baleeva
8
, N A Koziolova
9
, A S Veclich
9
, D V Duplyakov
10
, M N Maksimova
11
, S S Yakushin
12
, E A Smirnova
13
, E V Sedykh
12
, I I Shaposhnik
14
, N A Makarova
14
, A A Zemlyanukhina
15
, V V Skibitsky
16
, A V Fendrikova
16
, A V Skibitsky
16
, N A Spiropoulos
17
, E M Seredenina
1
, K A Eruslanova
18
, Yu V Kotovskaya
18
, O N Tkacheva
18
, M A Fedin
19
Affiliations
- 1 Lomonosov Medical Research and Educational Center.
- 2 National Medical Research Center for Therapy and Preventive Medicine.
- 3 People's Friendship University of Russia; Vinogradov Municipal Clinical Hospital.
- 4 Research Institute of Cardiology, Tomsk National Research Medical Center of the Russian Academy of Sciences.
- 5 Altai State Medical University; Altai Territorial Cardiological Dispensary.
- 6 Altai Territorial Cardiological Dispensary.
- 7 Research Institute for Complex Issues of Cardiovascular Diseases.
- 8 Kazan State Medical University.
- 9 Vagner Perm State Medical University.
- 10 Research Institute of Cardiology, Samara State Medical University; Polyakov Samara Regional Clinical Cardiological Dispensary.
- 11 Polyakov Samara Regional Clinical Cardiological Dispensary.
- 12 Pavlov Ryazan State Medical University; Ryazan Regional Clinical Cardiological Dispensary.
- 13 Ryazan Regional Clinical Cardiological Dispensary.
- 14 South Ural State Medical University.
- 15 Chelyabinsk Municipal Clinical Hospital #1.
- 16 Kuban State Medical University.
- 17 Clinical Hospital for Emergency Care.
- 18 Russian Gerontological Research and Clinical Center.
- 19 Russian Gerontological Research and Clinical Center; Pirogov Russian National Research Medical University.
Abstract
Aim To evaluate the incidence of iron deficiency (ID) in men and women with chronic heart failure (CHF) and to compare clinical and functional indexes in patient with and without ID depending on the gender.Material and methods An additional analysis of the study "Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (ID-CHF-RF)" was performed. The study included 498 (198 women, 300 men) patients with CHF, in whom, in addition to iron metabolism, the quality of life and exercise tolerance (ET) were studied. 97 % of patients were enrolled during their stay in a hospital. ID was defined in consistency with the European Society of Cardiology (ESC) Guidelines. Also, and additional analysis was performed according to ID criteria validated by the morphological picture of the bone marrow.Results ID was detected in 174 (87.9 %) women and 239 (79.8 %) men (p=0.028) according to the ESC criteria, and in 154 (77.8 %) women and 217 (72.3 %) men (p=0.208) according to the criteria validated by the morphological picture of the bone marrow. Men with ID were older and had more severe CHF. They more frequently had HF functional class (FC) III and IV (63.4 % vs. 43.3 % in men without ID); higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and lower ET. HF FC III increased the probability of ID presence 3.4 times (p=0.02) and the probability of HF FC IV 13.7 times (p=0.003). This clinical picture was characteristic of men when either method of determining ID was used. In women, ID was not associated with more severe CHF.Conclusion Based on the presented analysis, it is possible to characterize the male and female ID phenotypes. The male ID phenotype is associated with more severe CHF, low ET, and poor quality of life. In females of the study cohort, ID was not associated with either the severity of CHF or with ET.
MeSH terms
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Chronic Disease
-
Female
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Heart Failure* / complications
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Heart Failure* / diagnosis
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Heart Failure* / epidemiology
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Humans
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Iron Deficiencies*
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Male
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Phenotype
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Prevalence
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Quality of Life