Organic photoredox catalyzed C(sp3)-H functionalization of saturated aza-heterocycles via a cross-dehydrogenative coupling reaction

Yi-Fan Zhang; Han-Nan Chen; Yi Xiao; Zhencun Cui; Wei David Wang; Guo-Qiang Xu

doi:10.1039/d3ob01438j

Organic photoredox catalyzed C(sp³)-H functionalization of saturated aza-heterocycles via a cross-dehydrogenative coupling reaction

Org Biomol Chem. 2023 Oct 25;21(41):8284-8288. doi: 10.1039/d3ob01438j.

Authors

Yi-Fan Zhang¹, Han-Nan Chen¹, Yi Xiao¹, Zhencun Cui², Wei David Wang¹, Guo-Qiang Xu¹

Affiliations

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, MOE Frontiers Science Center for Rare Isotopes, Lanzhou Magnetic Resonance Center, Lanzhou University, Lanzhou 730000, P.R. China. ww@lzu.edu.cn.
² Department of Nuclear Medicine, MOE Frontiers Science Center for Rare Isotopes, Second Hospital of Lanzhou University, Lanzhou University, Lanzhou 730030, P.R. China.

PMID: 37814526
DOI: 10.1039/d3ob01438j

Abstract

Herein we present a novel protocol to access α-functionalized saturated aza-heterocycles, and a variety of nucleophilic groups, such as indole, naphthol, phenol, pyrrole, furyl, nitromethyl, and cyano, could be easily installed into saturated aza-heterocycles. Furthermore, a range of biologically valuable 3,3'-diindolylmethane derivatives could also be readily accessed under mild photocatalytic conditions.