Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis

Huiqiao Wang; Ruoyu Liu; Qi Sun; Kun Xu

doi:10.1039/d3cc04356h

Direct alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis

Chem Commun (Camb). 2023 Oct 24;59(85):12763-12766. doi: 10.1039/d3cc04356h.

Authors

Huiqiao Wang¹, Ruoyu Liu¹, Qi Sun², Kun Xu³

Affiliations

¹ College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
² Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230026, China. sunqi924@mail.ustc.edu.cn.
³ Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China. kunxu@bjut.edu.cn.

PMID: 37812023
DOI: 10.1039/d3cc04356h

Abstract

The metal-free alkylation of N-heterocycles with alkenes has remained a synthetic challenge. We report here the successful implementation of metal-free alkylation of quinoxalinones with electron-deficient alkenes enabled by a sequential paired electrolysis. This protocol provides a mechanistically distinct approach to prepare a variety of C-3 alkylated quinoxalinones that are otherwise quite difficult to synthesize by other means.