Ferroptosis, autophagy, tumor and immunity

Yuyan Xie; Yang Zhou; Jiale Wang; Lijuan Du; Yuanyuan Ren; Fang Liu

doi:10.1016/j.heliyon.2023.e19799

Ferroptosis, autophagy, tumor and immunity

Heliyon. 2023 Sep 5;9(9):e19799. doi: 10.1016/j.heliyon.2023.e19799. eCollection 2023 Sep.

Authors

Yuyan Xie¹, Yang Zhou¹, Jiale Wang¹, Lijuan Du¹, Yuanyuan Ren¹, Fang Liu¹

Affiliation

¹ Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.

Abstract

Ferroptosis was first proposed in 2012, a new form of cell death. Autophagy plays a crucial role in cell clearance and maintaining homeostasis. Autophagy is involved in the initial step of ferroptosis under the action of histone elements such as NCOA4, RAB7A, and BECN1. Ferroptosis and autophagy are involved in tumor progression, treatment, and drug resistance in the tumor microenvironment. In this review, we described the mechanisms of ferroptosis, autophagy, and tumor and immunotherapy, respectively, and emphasized the relationship between autophagy-related ferroptosis and tumor.

Keywords: Autophagy; Autophagy related ferroptosis; Ferroptosis; Immunity; Tumor; Tumor microenvironment.

Publication types

Review