Effects of two different paradigms of electrical stimulation exercise on cardio-metabolic risk factors after spinal cord injury. A randomized clinical trial

Ashraf S Gorgey; Refka E Khalil; William Carter; Boyd Ballance; Ranjodh Gill; Rehan Khan; Lance Goetz; Timothy Lavis; Adam P Sima; Robert A Adler

doi:10.3389/fneur.2023.1254760

Effects of two different paradigms of electrical stimulation exercise on cardio-metabolic risk factors after spinal cord injury. A randomized clinical trial

Front Neurol. 2023 Sep 22:14:1254760. doi: 10.3389/fneur.2023.1254760. eCollection 2023.

Authors

Ashraf S Gorgey^{1

2}, Refka E Khalil¹, William Carter², Boyd Ballance¹, Ranjodh Gill^{3

4}, Rehan Khan⁵, Lance Goetz^{1

2}, Timothy Lavis^{1

2}, Adam P Sima⁶, Robert A Adler^{3

4}

Affiliations

¹ Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, United States.
² Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond, VA, United States.
³ Endocrinology Service, Richmond VA Medical Center, Richmond, VA, United States.
⁴ Endocrine Division, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.
⁵ Radiology Service, Richmond VA Medical Center, Richmond, VA, United States.
⁶ Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States.

Abstract

Objective: To examine the combined effects of neuromuscular electrical stimulation-resistance training (NMES-RT) and functional electrical stimulation-lower extremity cycling (FES-LEC) compared to passive movement training (PMT) and FES-LEC in adults with SCI on (1) oxygen uptake (VO₂), insulin sensitivity and glucose disposal in adults with SCI; (2) Metabolic and inflammatory biomarkers; (3) skeletal muscle, intramuscular fat (IMF) and visceral adipose tissue (VAT) cross-sectional areas (CSAs).

Materials and methods: Thirty-three participants with chronic SCI (AIS A-C) were randomized to 24 weeks of NMES-RT + FES or PMT + FES. The NMES-RT + FES group underwent 12 weeks of evoked surface NMES-RT using ankle weights followed by an additional 12 weeks of progressive FES-LEC. The control group, PMT + FES performed 12 weeks of passive leg extension movements followed by an additional 12 weeks of FES-LEC. Measurements were performed at baseline (BL; week 0), post-intervention 1 (P1; week 13) and post-intervention 2 (P2; week 25) and included FES-VO₂ measurements, insulin sensitivity and glucose effectiveness using the intravenous glucose tolerance test; anthropometrics and whole and regional body composition assessment using dual energy x-ray absorptiometry (DXA) and magnetic resonance imaging to measure muscle, IMF and VAT CSAs.

Results: Twenty-seven participants completed both phases of the study. NMES-RT + FES group showed a trend of a greater VO₂ peak in P1 [p = 0.08; but not in P2 (p = 0.25)] compared to PMT + FES. There was a time effect of both groups in leg VO₂ peak. Neither intervention elicited significant changes in insulin, glucose, or inflammatory biomarkers. There were modest changes in leg lean mass following PMT + FES group. Robust hypertrophy of whole thigh muscle CSA, absolute thigh muscle CSA and knee extensor CSA were noted in the NMES-RT + FES group compared to PMT + FES at P1. PMT + FES resulted in muscle hypertrophy at P2. NMES-RT + FES resulted in a decrease in total VAT CSA at P1.

Conclusion: NMES-RT yielded a greater peak leg VO₂ and decrease in total VAT compared to PMT. The addition of 12 weeks of FES-LEC in both groups modestly impacted leg VO₂ peak. The addition of FES-LEC to NMES-RT did not yield additional increases in muscle CSA, suggesting a ceiling effect on signaling pathways following NMES-RT.

Clinical trial registration: identifier NCT02660073.

Keywords: functional electrical stimulation; neuromuscular electrical stimulation; rehabilitation; resistance training; spinal cord injury.

Associated data

ClinicalTrials.gov/NCT02660073