Multiple intra-abdominal fungal granulomas caused by Scedosporium apiospermum effectively treated with voriconazole in a Golden Retriever

Aritada Yoshimura; Ryuji Fukushima; Masaki Michishita; Miki Omura; Koichi Makimura; Daigo Azakami

doi:10.1016/j.mmcr.2023.100611

Multiple intra-abdominal fungal granulomas caused by Scedosporium apiospermum effectively treated with voriconazole in a Golden Retriever

Med Mycol Case Rep. 2023 Sep 28:42:100611. doi: 10.1016/j.mmcr.2023.100611. eCollection 2023 Dec.

Authors

Aritada Yoshimura¹, Ryuji Fukushima¹, Masaki Michishita², Miki Omura^{3

4}, Koichi Makimura⁴, Daigo Azakami^{1

5}

Affiliations

¹ Animal Medical Center, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo, 183-8509, Japan.
² Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
³ MycoLabo Inc, #101, 6-6-5-4 Shimorenjaku, Mitaka, Tokyo, 181-0013, Japan.
⁴ Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo, 192-0395, Japan.
⁵ Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo, 183-8509, Japan.

Abstract

Scedosporium apiospermum is a saprophytic filamentous fungus that is pathogenic to dogs. This report describes a case of S. apiospermum infection that caused multiple large peritoneal fungal granulomas in a dog with a history of jejunojejunostomy. The lesions were firmly attached to multiple organs and could not be surgically removed. In such cases, no precedent for the response to the treatment of this disease exists, and all affected dogs have died. This is the first report of an effective medical treatment for multiple intra-abdominal fungal granulomas using voriconazole.

Keywords: Dog; Fungal granuloma; Fungal infection; Scedosporium apiospermum; Voriconazole.

Publication types

Case Reports