The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases

Youngjo Kim

doi:10.1016/j.ceb.2023.102257

The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases

Curr Opin Cell Biol. 2023 Dec:85:102257. doi: 10.1016/j.ceb.2023.102257. Epub 2023 Oct 6.

Author

Youngjo Kim¹

Affiliation

¹ Department of Integrated Biomedical Science and Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheon-an 31151, Republic of Korea. Electronic address: yjokim@sch.ac.kr.

PMID: 37806292
DOI: 10.1016/j.ceb.2023.102257

Abstract

The role of lamin B1 in human health and aging has attracted increasing attention as mounting evidence reveals its significance in diverse cellular processes. Both upregulation and downregulation of lamin B1 have been implicated in age-associated organ dysfunctions and various human diseases, including central nervous system disorders. Additionally, lamin B1 levels undergo alterations in cancer cells, and a tumor-specific association exists between lamin B1 abundance and cancer aggressiveness. Investigating the connectivity between lamin B1 abundance and human health is of utmost importance for further research. This review presents recent advancements in understanding lamin B1's role in nuclear lamina function and its implications for human health.

Keywords: ADLD; Aging; Human diseases; Lamin B1; Lamins; Nucleus; Senescence.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging* / pathology
Humans
Lamin Type B / genetics
Neoplasms / pathology
Nuclear Lamina* / pathology

Substances

Lamin Type B