The updates on metastatic mechanism and treatment of colorectal cancer

Yunfei Ni; You Liang; Mingzhou Li; Yang Lin; Xin Zou; Fangyi Han; Jianing Cao; Liang Li

doi:10.1016/j.prp.2023.154837

The updates on metastatic mechanism and treatment of colorectal cancer

Pathol Res Pract. 2023 Nov:251:154837. doi: 10.1016/j.prp.2023.154837. Epub 2023 Oct 2.

Authors

Yunfei Ni¹, You Liang², Mingzhou Li¹, Yang Lin¹, Xin Zou¹, Fangyi Han¹, Jianing Cao¹, Liang Li³

Affiliations

¹ Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China.
² Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
³ Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China. Electronic address: lli@smu.edu.cn.

PMID: 37806170
DOI: 10.1016/j.prp.2023.154837

Abstract

Colorectal cancer (CRC) is a main cause of cancer death worldwide. Metastasis is a major cause of cancer-related death in CRC. The treatment of metastatic CRC has progressed minimally. However, the potential molecular mechanisms involved in CRC metastasis have remained to be comprehensively clarified. An improved understanding of the CRC mechanistic determinants is needed to better prevent and treat metastatic cancer. In this review, based on evidence from a growing body of research in metastatic cancers, we discuss the cellular and molecular mechanisms involved in CRC metastasis. This review reveals both the molecular mechanisms of metastases and identifies new opportunities for developing more effective strategies to target metastatic relapse and improve CRC patient outcomes.

Keywords: CTC; Colonization; Colorectal cancer; Dormancy; EMT; Metastatic mechanisms; Treatments.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / pathology
Colorectal Neoplasms* / therapy
Humans
Neoplasm Recurrence, Local