As a first-line classical drug, glucocorticoids are used in most combination treatment regimens of keloid. However, there are issues such as poor treatment efficacy and recurrence of keloid after keloid was treated with glucocorticoids, which seriously affect the therapeutic effect. In recent years, many studies have explored the factors influencing the efficacy of glucocorticoids in treating keloid and the action mechanism of glucocorticoids from different perspectives. Based on this, this paper reviews the mechanism and the factors influencing the efficacy of glucocorticoids in treating keloid, and explores ways to improve the treatment efficacy of glucocorticoids, aiming to provide thoughts for improving glucocorticoid-related diagnostic and therapeutic strategies.
糖皮质激素作为一线经典药物，在大多数瘢痕疙瘩的联合治疗中均有应用。然而用糖皮质激素药物治疗瘢痕疙瘩有效率低、治疗后存在瘢痕疙瘩复发等，严重影响治疗效果。近年来，许多研究从不同角度探讨了影响糖皮质激素治疗瘢痕疙瘩效果的因素及糖皮质激素的作用机制。基于此，该文综述了糖皮质激素治疗瘢痕疙瘩的机制和影响其疗效的因素，探讨了提高糖皮质激素治疗效果的方式，旨在为改进糖皮质激素相关诊疗方案提供思路。.