[Research advances on severe burn infection and cytokine storm]

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Apr 20;39(4):391-395. doi: 10.3760/cma.j.cn501225-20220412-00134.
[Article in Chinese]

Abstract

Mortality due to severe burns has always been at a high level. A large number of studies have shown that the rapid onset of infectious symptoms and rapid progression of severely burned patients are closely related to the occurrence of cytokine storm. However, in clinical practice, cytokine storm monitoring, early warning, and symptomatic treatment are still in exploratory stage. This article reviews the cytokine storm and its related cytokines, the mechanism, early warning, and treatment of cytokine storm induced by burn infection, aiming to provide clinical references for reducing infection and mortality in severely burned patients.

严重烧伤的致死率一直处于较高水平。大量研究表明,严重烧伤患者快速出现感染症状、病情进展迅速与细胞因子风暴的发生密切相关,然而临床实践中对细胞因子风暴的监测预警及对症治疗尚处于探索阶段。该文就细胞因子风暴及关联的细胞因子、烧伤感染诱发细胞因子风暴的机制、预警及治疗进行综述,旨在为减轻严重烧伤患者感染程度、降低病死概率提供临床参考建议。.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Burns* / drug therapy
  • Burns* / therapy
  • Cytokine Release Syndrome*
  • Cytokines
  • Humans

Substances

  • Cytokines