Neodymium and manganese ions co-doped whitlockite for temperature monitoring, photothermal therapy, and bone tissue repair in osteosarcoma

Chunning Heng; Xiaoyan Zheng; Junfeng Hui; Xiaoxuan Ma; Daidi Fan

doi:10.1016/j.jcis.2023.09.186

Neodymium and manganese ions co-doped whitlockite for temperature monitoring, photothermal therapy, and bone tissue repair in osteosarcoma

J Colloid Interface Sci. 2024 Jan;653(Pt B):1488-1503. doi: 10.1016/j.jcis.2023.09.186. Epub 2023 Oct 2.

Authors

Chunning Heng¹, Xiaoyan Zheng², Junfeng Hui¹, Xiaoxuan Ma³, Daidi Fan⁴

Affiliations

¹ Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.
² Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China. Electronic address: zy129@nwu.edu.cn.
³ Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, China. Electronic address: xiaoxuanma@nwu.edu.cn.
⁴ Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, China. Electronic address: fandaidi@nwu.edu.cn.

PMID: 37804617
DOI: 10.1016/j.jcis.2023.09.186

Abstract

Osteosarcoma is one of the most dangerous forms of tumors, leading to death in >90% of patients. The surgical treatment of osteosarcoma results in significant bone defects and risks of tumor recurrence. Using neodymium (Nd) and manganese (Mn) ions co-doped with whitlockite nanoparticle (Nd_10%Mn_10%WH NPs) and sodium alginate (SA), we designed and synthesized an organic-inorganic composite hydrogel (Nd_10%Mn_10%WH-SA) that displayed the excellent fluorescence and photothermal properties. Furthermore, the maximum fluorescence emission intensity of Nd_10%Mn_10%WH-SA at 1062 nm was linear with temperature. The optimal temperature for the treatment of tumors was determined by considering the changes in fluorescence intensity that led to a reduction in tissue damage around the tumors. Nd_10%Mn_10%WH NPs demonstrated a significant function in promoting human bone marrow mesenchymal stem cells (hBMSCs) proliferation. Furthermore, Nd_10%Mn_10%WH-SA could almost kill tumors when the photothermal temperature was raised to 50 °C, with a minimal leftover scar after photothermal therapy (PTT). Nd_10%Mn_10%WH-SA had a better promotion effect on the growth of the new bone. These results suggested that Nd_10%Mn_10%WH-SA offers a new PTT method for the "integrated treatment and repair" of osteosarcoma.

Keywords: Bone repair; Ion doping; Osteoma inhibition; PTT; Whitlockite.

MeSH terms

Bone Neoplasms* / therapy
Bone Regeneration
Bone and Bones
Humans
Manganese / pharmacology
Neodymium
Osteosarcoma* / therapy
Photothermal Therapy
Temperature

Substances

whitlockite
Neodymium
Manganese