Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension

Gaoxian Chen; Lorena Orozco; Sophia Parmisano; James W S Jahng; Carlos D Vera; Yan Zhuge; Joseph C Wu; Detlef Obal

doi:10.1016/j.scr.2023.103218

Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension

Stem Cell Res. 2023 Oct:72:103218. doi: 10.1016/j.scr.2023.103218. Epub 2023 Sep 30.

Authors

Gaoxian Chen¹, Lorena Orozco², Sophia Parmisano¹, James W S Jahng³, Carlos D Vera³, Yan Zhuge³, Joseph C Wu⁴, Detlef Obal⁵

Affiliations

¹ Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Human Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
³ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁴ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.
⁵ Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: obal@stanford.edu.

Abstract

Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500-1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the development of the disease. Here, we report two human induced pluripotent stem cell (iPSC) lines generated from IPAH patients. Both cell lines provide valuable insight into the molecular and cellular mechanisms of IPAH and can be used to further understand the disease.

Keywords: Induced pluripotent stem cells; Pulmonary arterial hypertension.

MeSH terms

Humans
Hypertension, Pulmonary* / genetics
Induced Pluripotent Stem Cells*
Mutation

Abstract

MeSH terms

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