Coccidioides species antifungal susceptibility testing: Experience from a large healthcare system in the endemic region

Med Mycol. 2023 Oct 5;61(10):myad104. doi: 10.1093/mmy/myad104.

Abstract

The clinical utility of Coccidioides species antifungal susceptibility testing (AST) remains unclear. This study describes the clinical course of eight patients with severe or chronic coccidioidomycosis and subsequent Coccidioides AST. We present the clinical manifestations, antifungal treatment regimens, and clinical outcomes for these patients.

Keywords: antifungal susceptibility; antifungal therapy; coccidioidomycosis.

Plain language summary

The role of antifungal susceptibility in the management of coccidioidomycosis remains unknown. This report presents cases of complex coccidioidomycosis where clinicians elected to conduct antifungal susceptibility testing as part of the treatment approach.

MeSH terms

  • Antifungal Agents* / pharmacology
  • Antifungal Agents* / therapeutic use
  • Coccidioides
  • Coccidioidomycosis* / diagnosis
  • Coccidioidomycosis* / drug therapy
  • Coccidioidomycosis* / epidemiology
  • Coccidioidomycosis* / veterinary
  • Humans

Substances

  • Antifungal Agents