Several studies have suggested that endoplasmic reticulum (ER) stress is important in the pathogenesis of infectious diseases; however, the precise function of ER stress regulation and the role of Herp as a regulator in Mtb H37Ra-induced ER stress remain elusive. Therefore, our study investigated ER stress and autophagy associated with Herp expression in Mycobacterium tuberculosis-infected macrophages to determine the role of Herp in the pathogenesis of tuberculosis.
Keywords: ER stress; ER-associated degradation; Mycobacterium tuberculosis; autophagy; homocysteine-inducible ER protein with ubiquitin-like domain 1; reactive oxygen species.