Iodine-induced thyroid dysfunction: a scientometric study and visualization analysis

Boshen Gong; Xichang Wang; Chuyuan Wang; Wanyu Yang; Zhongyan Shan; Yaxin Lai

doi:10.3389/fendo.2023.1239038

Iodine-induced thyroid dysfunction: a scientometric study and visualization analysis

Front Endocrinol (Lausanne). 2023 Sep 20:14:1239038. doi: 10.3389/fendo.2023.1239038. eCollection 2023.

Authors

Boshen Gong¹, Xichang Wang¹, Chuyuan Wang¹, Wanyu Yang¹, Zhongyan Shan¹, Yaxin Lai¹

Affiliation

¹ Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Council (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Abstract

Objective: Iodine is essential in thyroid hormone production. Iodine deficiency is associated with serious complications (i.e miscarriage and stillbirth), whereas excess can cause thyroid dysfunction (i.e hyperthyroidism, hypothyroidism, thyroid autoimmunity). We conducted this scientometric study to visualize hot spots and trends in iodine-induced thyroid dysfunction over past two decades. The aim of this paper was to help scholars quickly understand the development and potential trend in this field, and guide future research directions.

Methods: Articles on iodine-induced thyroid dysfunction from 2000 to 2022 were retrieved from the Web of Science Core Collection (WoSCC) using the following search terms: (((((TS=(hypothyroid*)) OR TS=(hyperthyroid*)) OR TS= ("TSH deficiency")) OR TS= ("thyroid stimulating hormone deficiency")) AND TS=(Iodine)) NOT TS=(radioiodine). Only publications in English were selected. CiteSpace, VOSviewer, Tableau, Carrot2, and R software were used to analyze the contribution and co-occurrence relationships of different countries, institutes, keywords, references, and journals.

Results: A total of 2986 publications from 115 countries and 3412 research institutions were included. From 2000 to 2022, research on iodine-induced thyroid dysfunction progressed over a three-stage development period: initial development (2000-2009), stable development (2010-2016), and rapid development (2016-2022) period. The Journal of Clinical Endocrinology and Metabolism had the most co-citations followed and China Medical University (n=76) had the most publications. The top three clusters of co-citation references were isolated maternal hypothyroxinemia, subclinical hyperthyroidism, and brain development. Various scientific methods were applied to reveal acknowledge structure, development trend and research hotspots in iodine-induced thyroid dysfunction.

Conclusion: Our scientometric analysis shows that investigations related to pregnant women, epidemiology surveys, and iodine deficiency are promising topics for future iodine-induced thyroid dysfunction research and highlights the important role of iodine on thyroid function.

Keywords: hyperthyroidism; hypothyroidism; iodine; pregnant women; scientometric study; thyroid dysfunction; visualization analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Hyperthyroidism* / chemically induced
Hyperthyroidism* / complications
Hypothyroidism*
Iodine Radioisotopes
Iodine* / adverse effects
Malnutrition*
Pregnancy

Substances

Iodine
Iodine Radioisotopes

Grants and funding

This study was supported by the Chinese National Natural Science Foundation (grants 82270836), and Natural Science Foundation of Liaoning Province (grants LJKZ0742).