High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study

Andrea Franco-Oliva; Beatriz Adriana Pinzón-Navarro; Martha C Martínez-Soto-Holguín; Ximena León-Lara; Javier Ordoñez-Ortega; Ana Laura Pardo-Gutiérrez; Martha Guevara-Cruz; Azalia Avila-Nava; Alda Daniela García-Guzmán; Laura Guevara-Pedraza; Isabel Medina-Vera

doi:10.3389/fnut.2023.1220013

High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study

Front Nutr. 2023 Sep 20:10:1220013. doi: 10.3389/fnut.2023.1220013. eCollection 2023.

Authors

Andrea Franco-Oliva^{1

2}, Beatriz Adriana Pinzón-Navarro^{3

4}, Martha C Martínez-Soto-Holguín³, Ximena León-Lara⁵, Javier Ordoñez-Ortega⁶, Ana Laura Pardo-Gutiérrez¹, Martha Guevara-Cruz^{4

7}, Azalia Avila-Nava⁸, Alda Daniela García-Guzmán^{4

9}, Laura Guevara-Pedraza¹⁰, Isabel Medina-Vera^{1

4}

Affiliations

¹ Departamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México, Mexico.
² Maestría en Nutrición Clínica, Escuela de Dietética y Nutrición del ISSSTE, Ciudad de México, México.
³ Servicio de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, Ciudad de México, Mexico.
⁴ Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, Mexico.
⁵ Institute of Immunology, Hannover Medical School, Hannover, Germany.
⁶ Departamento de Infectología Pediátrica, Instituto Nacional de Pediatría, Ciudad de México, Mexico.
⁷ Departamento de Fisiología de la Nutrición, Instituto Nacional de Nutrición y Ciencias Médicas Salvador Zubirán, Ciudad de México, Mexico.
⁸ Unidad de Investigación, Hospital Regional de Alta Especialidad de la Península de Yucatán, Mérida, Yucatán, Mexico.
⁹ Servicio de Oncología Médica, Instituto Nacional de Pediatría, Ciudad de México, Mexico.
¹⁰ Universidad Anahuac, Ciudad de México, Mexico.

Abstract

Background and aims: Many improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. Current nutritional recommendations are based on studies performed in adults, with limited data on the HIV-infected pediatric population. Therefore, this study aimed to compare the resting energy expenditure (REE) of asymptomatic HIV-infected pediatric patients with healthy counterparts and to compare body composition, dietary intake, and physical activity between the two groups.

Methods: This was a cross-sectional study of asymptomatic HIV-infected children who were receiving antiretroviral therapy; the infected group was compared with the uninfected group, matched by age (± 6 months), sex, and body mass index (± 0.5 z-score). Participants were recruited between 2021 and 2022, as outpatients. In both groups, REE was determined by indirect calorimetry and body composition by bioelectrical impedance analysis and hand strength, measured using a hydraulic hand dynamometer.

Results: Seventy-eight participants were enrolled, where n = 39 HIV-infected children and n = 39 controls, with a mean age of 11.6 ± 3.4 years old. REE was significantly higher in the HIV group (1254.4 ± 334.7 kcal/day vs. 1124.7 ± 321 kcal/day, p = 0.013) than in the control group. Fat-free mass (FFM) was lower in the HIV group (28.2 ± 10.5 kg vs. 32 ± 11.2 kg, p = 0.001); this trend continued when the index skeletal muscle was evaluated (7.2 ± 1.2 vs. 7.6 ± 1.5, p = 0.04). The strength of the dominant hand was also lower in the HIV group (12 (8-18) kg vs. 20 (10.5-26) kg, p < 0.0001).

Conclusions: Children with asymptomatic HIV infection have higher REE than their uninfected peers. They also present decreased FFM, skeletal muscle mass index, and muscle strength. These parameters should be considered during nutritional assessment in this population to have a favorable impact on nutritional status and growth.

Keywords: HIV-infected; adolescents; children; fat free mass; handgrip strength; resting energy expenditure.

Grants and funding

The publication was financed by the Recurso Fiscal of Instituto Nacional de Pediatría. AF-O received a scholarship from Instituto Danone de México. The project was partially financed by a grant from the Concurso de Proyectos de Investigación en Nutrición Pediátrica para Investigadores Jóvenes de Latinoamérica 2020 of the Sociedad Latinoamericana de Gastroenterología Hepatología y nutrición Pediátrica (LASPGHAN) to MCM-S-H, XL-L, MG-C, and IM-V.