Disposable rocking bioreactors: recent applications and progressive perspectives

Kamil Wierzchowski; Maciej Pilarek

doi:10.1016/j.tibtech.2023.09.003

Disposable rocking bioreactors: recent applications and progressive perspectives

Trends Biotechnol. 2024 Mar;42(3):261-264. doi: 10.1016/j.tibtech.2023.09.003. Epub 2023 Oct 3.

Authors

Kamil Wierzchowski¹, Maciej Pilarek²

Affiliations

¹ Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, Poland.
² Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, Poland. Electronic address: maciej.pilarek@pw.edu.pl.

PMID: 37798143
DOI: 10.1016/j.tibtech.2023.09.003

Abstract

Disposable rocking bioreactors facilitate scaling up animal and plant cell biomass propagation and developing specified bioprocesses like manufacturing vaccines or chimeric antigen receptor (CAR) T cells. Future contexts for these bioreactors include supporting regenerative medicine, recognising metabolic responses of biochemically or mechanically stressed cells, continuously performing in vitro bioprocesses, or cell-free protein synthesis systems.

Keywords: bioprocess scale-up; fragile biomass propagation; in vitro bioprocessing; rocking bioreactors; wave-type mixing.

MeSH terms

Animals
Biomass
Bioreactors*
Cell Culture Techniques*
Plant Cells