The role of circadian clock genes in colorectal carcinoma: Novel insights into regulatory mechanism and implications in clinical therapy

Haodong Zhu; Jiawei Chen; Zeqin Wen; Jinfei Li; Qinyang Yu; Weihua Liao; Xiangjian Luo

doi:10.1016/j.lfs.2023.122145

The role of circadian clock genes in colorectal carcinoma: Novel insights into regulatory mechanism and implications in clinical therapy

Life Sci. 2023 Nov 15:333:122145. doi: 10.1016/j.lfs.2023.122145. Epub 2023 Oct 4.

Authors

Haodong Zhu¹, Jiawei Chen¹, Zeqin Wen², Jinfei Li¹, Qinyang Yu¹, Weihua Liao³, Xiangjian Luo⁴

Affiliations

¹ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.
² Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China.
³ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China.
⁴ Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China; Key Laboratory of Biological Nanotechnology of National Health Commission, Central South University, Changsha, Hunan 410078, PR China; Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China; Molecular Imaging Research Center of Central South University, Changsha, Hunan 410078, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410078, PR China. Electronic address: luocsu@csu.edu.cn.

PMID: 37797685
DOI: 10.1016/j.lfs.2023.122145

Abstract

Colorectal cancer (CRC) is a lethal malignancy with limited treatment strategies. Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are intimately associated with circadian clock, an inherent 24-h cycle oscillation of biochemical, physiological functions in almost every eukaryote. In the present review, we summarize the altered expression level of circadian genes in CRC and the prognosis associated with gene abundance switch. We illustrate the function and potential mechanisms of circadian genes in CRC pathogenesis and progression. Moreover, circadian based-therapeutic strategies including chronotherapy, therapeutics targeting potential circadian components, and melatonin treatment in CRC are also highlighted.

Keywords: Cancer therapy; Circadian genes; Colorectal cancer.

Publication types

Review

MeSH terms

Carcinogenesis
Circadian Clocks* / genetics
Circadian Rhythm / genetics
Colorectal Neoplasms* / drug therapy
Colorectal Neoplasms* / genetics
Humans