A call to implement preclinical study registration in animal ethics review

Matthew S Jeffers; Aileen MacLellan; Marc T Avey; Julia Ml Menon; Janet Sunohara-Neilson; Dean A Fergusson; Manoj M Lalu

doi:10.1371/journal.pbio.3002293

A call to implement preclinical study registration in animal ethics review

PLoS Biol. 2023 Oct 5;21(10):e3002293. doi: 10.1371/journal.pbio.3002293. eCollection 2023 Oct.

Authors

Matthew S Jeffers^{1

2}, Aileen MacLellan³, Marc T Avey⁴, Julia Ml Menon⁵, Janet Sunohara-Neilson⁶, Dean A Fergusson^{1

2

7}, Manoj M Lalu^{1

2}

Affiliations

¹ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
² School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
³ Department of Integrative Biology, University of Guelph, Guelph, Canada.
⁴ Canadian Council on Animal Care, Ottawa, Canada.
⁵ Preclinicaltrials.eu, Netherlands Heart Institute, Utrecht, the Netherlands.
⁶ Animal Care and Veterinary Services, Western University, London, Canada.
⁷ Department of Medicine, University of Ottawa, Ottawa, Canada.

Abstract

Protocol registration is required in clinical trials. Registration of animal studies could improve research transparency and reduce redundancy, yet uptake has been minimal. Integrating study registration into institutional approval of animal use protocols is a promising approach to increase uptake.

Copyright: © 2023 Jeffers et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

MeSH terms

Animals
Ethics Committees, Research*
Research*

Grants and funding

The Ontario Graduate Scholarship (MSJ), Canadian Institutes of Health Research sponsored Vanier Canada Graduate Scholarship (CGV-186957 to MSJ), The Ottawa Hospital Anesthesia Alternate Funds Association (MML), University of Ottawa Junior Research Chair in Innovative Translational Research (MML), and Canadian Anesthesia Research Foundation sponsored Canadian Anesthesiologists' Society Career Scientist Award (MML) provided funding that supported this work. The funders had no role in design, decision to publish, or preparation of the manuscript.