Associations of lipid accumulation product, visceral adiposity index, and triglyceride-glucose index with subclinical organ damage in healthy Chinese adults

Front Endocrinol (Lausanne). 2023 Sep 19:14:1164592. doi: 10.3389/fendo.2023.1164592. eCollection 2023.

Abstract

Background and aims: Obesity is an independent risk factor for cardiovascular disease development. Here, we aimed to examine and compare the predictive values of three novel obesity indices, lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose (TyG) index, for cardiovascular subclinical organ damage.

Methods: A total of 1,773 healthy individuals from the Hanzhong Adolescent Hypertension Study cohort were enrolled. Anthropometric, biochemical, urinary albumin-to-creatinine ratio (uACR), brachial-ankle pulse wave velocity (baPWV), and Cornell voltage-duration product data were collected. Furthermore, the potential risk factors for subclinical organ damage were investigated, with particular emphasis on examining the predictive value of the LAP, VAI, and TyG index for detecting subclinical organ damage.

Results: LAP, VAI, and TyG index exhibited a significant positive association with baPWV and uACR. However, only LAP and VAI were found to have a positive correlation with Cornell product. While the three indices did not show an association with electrocardiographic left ventricular hypertrophy, higher values of LAP and TyG index were significantly associated with an increased risk of arterial stiffness and albuminuria. Furthermore, after dividing the population into quartiles, the fourth quartiles of LAP and TyG index showed a significant association with arterial stiffness and albuminuria when compared with the first quartiles, in both unadjusted and fully adjusted models. Additionally, the concordance index (C-index) values for LAP, VAI, and TyG index were reasonably high for arterial stiffness (0.856, 0.856, and 0.857, respectively) and albuminuria (0.739, 0.737, and 0.746, respectively). Lastly, the analyses of continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI) demonstrated that the TyG index exhibited significantly higher predictive values for arterial stiffness and albuminuria compared with LAP and VAI.

Conclusion: LAP, VAI, and, especially, TyG index demonstrated utility in screening cardiovascular subclinical organ damage among Chinese adults in this community-based sample. These indices have the potential to function as markers for early detection of cardiovascular disease in otherwise healthy individuals.

Keywords: albuminuria; arterial stiffness; left ventricular hypertrophy; lipid accumulation product; subclinical organ damage; triglyceride-glucose index; visceral adiposity index.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity
  • Adult
  • Albuminuria / diagnosis
  • Ankle Brachial Index
  • Blood Glucose / analysis
  • Cardiovascular Diseases* / diagnosis
  • Cardiovascular Diseases* / epidemiology
  • Cardiovascular Diseases* / etiology
  • East Asian People
  • Glucose
  • Humans
  • Lipid Accumulation Product*
  • Obesity
  • Pulse Wave Analysis
  • Triglycerides

Substances

  • Blood Glucose
  • Glucose
  • Triglycerides

Grants and funding

This work was supported by the National Natural Science Foundation of China Nos. 82070437 and 81870319 (J-JM) and No. 81600327 (YW), the Natural Science Basic Research Program of Shaanxi Province (2021JM-257, 2021JM-588), the Key R&D Projects in Shaanxi Province Grant No. 2020ZDLFY08-04, the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University of China Nos. XJTU1AF-CRF-2022-002 and XJTU1AF2021CRF-021, the Basic-Clinical Integration Innovation Project in Medicine of Xi’an Jiaotong University (YXJLRH2022009), the Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University Nos. 2022MS-36 and 2021ZXY-14 (YW), the Key R&D Projects in Shaanxi Province Grant No. 2023-ZDLSF-50; the Chinese Academy of Medical Sciences & Peking Union Medical College (2017-CXGC03-2), and the International Joint Research Center for Cardiovascular Precision Medicine of Shaanxi Province (2020GHJD-14).