Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations

Donato Rigante; Chiara Leoni; Roberta Onesimo; Valentina Giorgio; Valentina Trevisan; Giuseppe Zampino

doi:10.1016/j.autrev.2023.103462

Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations

Autoimmun Rev. 2023 Nov;22(11):103462. doi: 10.1016/j.autrev.2023.103462. Epub 2023 Oct 2.

Authors

Donato Rigante¹, Chiara Leoni², Roberta Onesimo², Valentina Giorgio³, Valentina Trevisan², Giuseppe Zampino³

Affiliations

¹ Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica Sacro Cuore, Rome, Italy. Electronic address: donato.rigante@unicatt.it.
² Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
³ Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica Sacro Cuore, Rome, Italy.

PMID: 37793491
DOI: 10.1016/j.autrev.2023.103462

No abstract available

Keywords: Autoimmune thyroiditis; Autoimmunity; Loose anagen hair syndrome; Mazzanti syndrome; Myristoylation; Noonan syndrome; Personalized medicine; RAS/MAPK signaling; RASopathies; SHOC2.

Publication types

Letter

MeSH terms

Humans
Intracellular Signaling Peptides and Proteins*
Mutation
Phenotype

Substances

SHOC2 protein, human
Intracellular Signaling Peptides and Proteins