Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes

Cell Metab. 2023 Oct 3;35(10):1677-1679. doi: 10.1016/j.cmet.2023.09.008.

Abstract

The role of the gut microbiome in metabolic diseases, such as diabetes, has emerged as a pivotal area of medical research. Wang et al.'s recent work reported that a gut bacteria-derived microbial-host isozyme, mimicking a human enzyme responsible for blood glucose regulation, can significantly impact the efficacy of diabetes medications.

Publication types

  • Comment

MeSH terms

  • Bacteria / metabolism
  • Diabetes Mellitus* / drug therapy
  • Gastrointestinal Microbiome* / physiology
  • Humans
  • Isoenzymes / metabolism
  • Metabolic Diseases*

Substances

  • Isoenzymes