Death-seq and ye shall find: A novel screening strategy for dying cells

Ryan Wallis; Cleo L Bishop

doi:10.1016/j.cmet.2023.09.003

Death-seq and ye shall find: A novel screening strategy for dying cells

Cell Metab. 2023 Oct 3;35(10):1675-1676. doi: 10.1016/j.cmet.2023.09.003.

Authors

Ryan Wallis¹, Cleo L Bishop²

Affiliations

¹ Blizard Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.
² Blizard Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK. Electronic address: c.l.bishop@qmul.ac.uk.

PMID: 37793342
DOI: 10.1016/j.cmet.2023.09.003

Abstract

Killing senescent cells to improve health-span holds great promise. However, screening for senescence-regulating genes and molecules is challenging because these cells do not proliferate. In this issue, Colville and Liu et al. develop Death-seq, a positive selection screening tool that overcomes this hurdle to offer broad genetic and pharmacological utility.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Apoptosis*
Cellular Senescence* / genetics