68 Ga-FAPI has been introduced recently in many nuclear medicine centers. Many pitfalls have been discussed previously. However, not all pitfalls are currently addressed in the literature. To our knowledge, this is the first reported case to address nonspecific 68 Ga-FAPI expression at anorectal sphincter. A 69-year-old woman was diagnosed with intrahepatic cholangiocarcinoma. A 68 Ga-FAPI scan was performed after diagnostic workup and chemoradiotherapy. In addition to 68 Ga-FAPI-avid lesion at primary site, several nononcological ancillary findings have been observed. This includes unaddressed 68 Ga-FAPI-avid focus within anorectal sphincter. Moreover, the same noteworthy findings were observed in the musculoskeletal and gynecological systems.
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