Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector

Andrew J Hall; Amy G Robertson; Robert W Baker; Leila R Hill; Louis M Rendina

doi:10.1039/d3cc02706f

Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector

Chem Commun (Camb). 2023 Oct 17;59(83):12511-12514. doi: 10.1039/d3cc02706f.

Authors

Andrew J Hall¹, Amy G Robertson¹, Robert W Baker¹, Leila R Hill¹, Louis M Rendina^{1

2}

Affiliations

¹ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. louis.rendina@sydney.edu.au.
² The University of Sydney Nano Institute, Sydney, NSW 2006, Australia.

PMID: 37789720
DOI: 10.1039/d3cc02706f

Abstract

The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching 1200%, over the parent triphenylphosphonium salts. DFT and quantum chemical topology analyses support a new type of conformationally-dependent tumour cell targeting vector.

MeSH terms

Gadolinium* / chemistry
Gadolinium* / pharmacology
Humans
Neoplasms* / pathology

Substances

Gadolinium