Secondary Analysis of Agreement Between Negative Timeline Follow Back Report and Negative Urine Toxicology in a Large Trial of Individuals with Opioid Use Disorder

J Addict Med. 2023 Sep-Oct;17(5):618-620. doi: 10.1097/ADM.0000000000001173. Epub 2023 May 17.

Abstract

Objectives: Timeline follow-back (TLFB) is a self-report measure commonly used as a method of assessing historical drug use in both clinical and research settings. Our study considered rates of agreement between TLFB and an objective biological assay of opioid use.

Methods: We calculated the rates of agreement between negative report of opioid use for the most recent 8 days on TLFB and urine toxicology (UTOX) results in a large multisite opioid use disorder treatment trial.

Results: In total, 3986 assessments were provided by trial participants with both UTOX and TLFB during weeks 1 to 12, 2716 during weeks 13 to 24, and 325 at week 28. Rates of disagreement between negative TLFB and positive opioid UTOX were 2.33% of all assessments (21.68% of those with positive UTOX) over weeks 1 to 12, 2.06% of all assessment (25.00% of those with positive UTOX) over weeks 13 to 24, and 9.85% of all assessments (26.02% of those with positive UTOX) at week 28.

Conclusions: Negative TLFB seems to be generally associated with negative results on urine toxicology.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analgesics, Opioid* / adverse effects
  • Clinical Trials as Topic
  • Humans
  • Multicenter Studies as Topic
  • Opioid-Related Disorders* / drug therapy
  • Self Report

Substances

  • Analgesics, Opioid