Advances in the study of the relationship between Alzheimer's disease and the gastrointestinal microbiome

Xin-Yan Li; Hao-Yue Qin; Ting-Ting Li

doi:10.1002/ibra.12065

Advances in the study of the relationship between Alzheimer's disease and the gastrointestinal microbiome

Ibrain. 2022 Sep 8;8(4):465-475. doi: 10.1002/ibra.12065. eCollection 2022 Winter.

Authors

Xin-Yan Li¹, Hao-Yue Qin¹, Ting-Ting Li^{2

3}

Affiliations

¹ Southwest Medical University Luzhou Sichuan China.
² Department of Anesthesiology, Institute of Neurological Disease, West China Hospital Sichuan University Chengdu China.
³ Department of Anestheiology, West China Tianfu Hospital Sichuan University Chengdu China.

Abstract

There are many trillions of bacteria in the gastrointestinal microbiome (GM). Their ecological dysregulation can contribute to the development of certain neurodegenerative diseases, including Alzheimer's disease (AD). AD is common dementia and its incidence is increasing year by year. However, the relationship between GM and AD is unclear. Therefore, this review discusses the relationship between GM and AD, elaborates on the possible factors that can affect this relationship through the inflammation of the brain induced by blood-brain damage and accumulation of amyloid deposit, and proposes feasible ways to treat AD through GM-related substances, such as probiotics, Mega-3, and gut hormones, including their shortcomings as well.

Keywords: Alzheimer's disease; gastrointestinal microbiome; gut hormones; probiotics; short‐chain fatty acids.

Publication types

Review