Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

Gülçin Günal; Dincer Gokcen; Halil Murat Aydin

doi:10.1021/acsabm.3c00557

Extracellular Matrix-Based Conductive Composites for Myocardial Tissue Regeneration

ACS Appl Bio Mater. 2023 Oct 16;6(10):4100-4104. doi: 10.1021/acsabm.3c00557. Epub 2023 Oct 2.

Authors

Gülçin Günal^{1

2}, Dincer Gokcen³, Halil Murat Aydin^{1

4}

Affiliations

¹ Bioengineering Division, Institute of Science, Hacettepe University, Beytepe, 06800 Ankara, Turkey.
² Department of Plastic Surgery, Akdeniz University, Konyaaltı, 07058 Antalya, Turkey.
³ Department of Electrical and Electronics Engineering, Faculty of Engineering, Hacettepe University, Beytepe, 06800 Ankara, Turkey.
⁴ Centre for Bioengineering, Hacettepe University, Beytepe, 06800 Ankara, Turkey.

PMID: 37782232
DOI: 10.1021/acsabm.3c00557

Abstract

Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young's modulus of the composite elastomer were found as 5 × 10^-3 ± 1 × 10^-3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.

Keywords: Cardiac patch; conductive biomaterial; extracellular matrix; multiwalled carbon nanotubes; poly(glycerol-sebacate).

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Elastomers / chemistry
Extracellular Matrix
Myocardium
Nanotubes, Carbon* / chemistry
Nanotubes, Carbon* / toxicity
Tissue Engineering

Substances

Nanotubes, Carbon
Elastomers