Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Yixiu Zhong; Youfan Zhang; Aijiao Yu; Zhiwen Zhang; Zhenjun Deng; Kaifen Xiong; Qi Wang; Jianglin Zhang

doi:10.3389/fphys.2023.1247734

Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Front Physiol. 2023 Sep 12:14:1247734. doi: 10.3389/fphys.2023.1247734. eCollection 2023.

Authors

Yixiu Zhong¹, Youfan Zhang², Aijiao Yu^{3

4}, Zhiwen Zhang^{3

4}, Zhenjun Deng¹, Kaifen Xiong⁵, Qi Wang², Jianglin Zhang¹

Affiliations

¹ Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
² Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
³ Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.
⁴ Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
⁵ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body's physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.

Keywords: conditioned medium; exosomes; hypertrophic scar; keloid; mesenchymal stem cell.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (82073019, 82073018, and 82202851), Shenzhen Science and Technology Innovation Commission, China (Natural Science Foundation of Shenzhen), (JCYJ20210324113001005, JCYJ20210324114212035, and JCYJ20220530151817038). This work was supported by Grant No. from the National Natural Science Foundation; and Grant No. from Shenzhen Science and Technology Planning Project.